Reedsburg jumped out to a big lead on Portage thanks to big nights from running back Tyler Reynolds and quarterback Will Decorah.
Waunakee led 7-0 in the first until Reynolds rushed 18 yards for a touchdown to make it 14-0.
They put up 28 more points en route to the blowout win over Portage.
Waunkee remains unbeaten at 4-0 with the 41-0 win. Portage drops to 2-2.